One of the biggest catalysts right now in biotech and biopharmaceuticals is immuno-oncology. And one of the biggest regions for this research is the Bay Area.
Merck’s Dan Cua is in the middle of it all.
As a senior principal scientist in Immuno-Oncology Discovery, Dan currently works at Merck Research Laboratories' Palo Alto site (which will be relocated to South San Francisco in 2019) and is an expert in the field of immunology, an area that will help to advance Merck’s world-class immuno-oncology research.
His interests include cell death, NF-kβ signaling, role of ubiquitin modification in disease pathogenesis, and characterizing regulatory complexes within the innate immune system, especially, the Inflammasome.
A historical perspective of his contributions is documented in three accounts published in Nature (2008, 453:271-273), Nature Cell Biology (2010, 12(5): 415) and The Journal of Immunology (2013, 190:3-4).
Ana I Domingos currently works at the Obesity Laboratory, Instituto Gulbenkian de Ciência (IGC) and is an Associate Professor of Neuroscience at the University of Oxford. Ana does research in Obesity while integrating aspects of Neuroscience and Innate Immunity. The laboratory of Dr Domingos focuses on neuroimmune mechanisms underlying obesity. Using optogenetics and multiphoton microscopy, among other tools, the laboratory of Dr Domingos has recently discovered a direct connection between adipocytes and the sympathetic nervous system (SNS). Howard Hughes Medical Institute, the Welcome Trust, the Human Frontiers Science Program, the European Molecular Biology Organization, and the Gulbenkian Foundation fund the laboratory of Dr Domingos. She has undergraduate training in mathematics, doctoral training in neurobiology mentored by Prof. Dr Leslie Vosshall and postdoctoral training in metabolism mentored by Prof. Dr Jeffrey Friedman, both at the Rockefeller University.
Florent Ginhoux graduated in Biochemistry from the University Pierre et Marie CURIE (UPMC), Paris VI, obtained a Masters degree in Immunology from the Pasteur Institute in 2000 and his PhD in 2004 from UPMC, Paris VI. As a postdoctoral fellow, he joined the Laboratory of Miriam Merad in the Mount Sinai School of Medicine (MSSM), New York.
In 2008, he became an Assistant Professor in the Department of Gene and Cell Medicine, MSSM and member of the Immunology Institute of MSSM. He joined the Singapore Immunology Network (SIgN), A*STAR in May 2009 as a Junior Principal Investigator. He is now a Senior Principal Investigator and an EMBO Young Investigator and his laboratory is focusing on the ontogeny and differentiation of macrophages and dendritic cells in both humans and mice
Vera Gorbunova is an endowed Professor of Biology at the University of Rochester and a co-director of the Rochester Aging Research Center. Her research is focused on understanding the mechanisms of longevity and genome stability and on the studies of exceptionally long-lived mammals. Dr. Gorbunova earned her B.Sc. degrees at Saint Petersburg State University, Russia and her Ph.D. at the Weizmann Institute of Science, Israel. Dr. Gorbunova pioneered comparative biology approach to study aging and identified rules that control evolution of tumor suppressor mechanisms depending on the species lifespan and body mass. Dr. Gorbunova also investigates the role of Sirtuin proteins in maintaining genome stability. More recently the focus of her research has been on the longest-lived rodent species the naked mole rats and the blind mole rat. Dr. Gorbunova identified high molecular weight hyaluronan as the key mediator of cancer-resistance in the naked mole rat. Her work received awards of from the Ellison Medical Foundation, the Glenn Foundation, American Federation for Aging Research, and from the National Institutes of Health. Her work was awarded the Cozzarelli Prize from PNAS, prize for research on aging from ADPS/Alianz, France, Prince Hitachi Prize in Comparative Oncology, Japan, and Davey prize from Wilmot Cancer Center.
Professor Elizabeth Hartland is the Director and CEO of Hudson Institute of Medical Research and the Head of the Department of Molecular and Translational Science at Monash University. Prior to joining the Hudson Institute, Professor Hartland held the positions of Head of the Department of Microbiology and Immunology, University of Melbourne, Deputy Director of the Doherty Institute for Infection and Immunity and Acting Pro-Vice Chancellor Research Partnerships and External Relations at the University of Melbourne. Professor Hartland undertook her undergraduate and graduate training in biochemistry and microbiology at the University of Melbourne. She has held a Royal Society/NHMRC Howard Florey Fellowship in the Department of Biochemistry, Imperial College London and Lecturer/Senior Lecturer positions at Monash University. She was an inaugural Australian Research Council Future Fellow at the University of Melbourne. Professor Hartland has a long-standing research interest in the pathogenesis of infections caused by bacterial pathogens, with a focus on the genetic mechanisms of microbial colonization and immune evasion.
Prof. Holmes is the Head of the Division of Computational and Systems Medicine and a Professor of Chemical Biology in the Department of Surgery and Cancer at Imperial College, in London, UK. She has over 20 years’ experience in metabonomic technology and its applications. Her focus is on the discovery and development of metabolic biomarkers of disease in personalised healthcare and population studies with significant contributions to cardiovascular, neuroscience and infectious disease research.
Recently Prof. Holmes has driven large-scale profiling efforts defining the concept of the metabolome-wide association study (MWAS) in molecular epidemiology, specifically exploring the link between hypertension, diet and metabolic profiles. She has also developed methods for characterizing gut microbiome host metabolic interactions and has applied these to the study of gastrointestinal related diseases including colorectal cancer, obesity and IBD. She also has an established track record in the development of chemometric and statistical methods for analysis of Omics data.
Paul Kubes is the Snyder Research Chair in the Department of Critical Care Medicine at the University of Calgary and a Canada Research Chair. He studied at Queen’s University and Louisiana State University. He has devoted much of his time to investigating the role of leukocyte recruitment in various inflammatory diseases using cutting edge imaging techniques in vivo. He is the founding director of the Calvin, Phoebe and Joan Snyder Institute of Infection, Immunity and Inflammation.
Professor Luke O’Neill holds the Chair of Biochemistry at Trinity College Dublin where he leads the Inflammation Research Group. He has a PhD in Pharmacology from the University of London and carried out Post-Doctoral research at Cambridge U.K. His research is in the area of the molecular basis to inflammation with a particular focus on innate immunity, Toll-like receptors, inflammasomes and metabolic reprogramming in inflammation.
In 2016 he was named by Clarivates/Thompson Reuters as one of the world’s most influential scientists, being in the top 1% in Immunology. He is co-founder of 2 Spin-out companies - Opsona Therapeutics and Inflazome, which is developing new treatments for inflammatory diseases. He was elected a Fellow of the Royal Society in 2016.
Michal Schwartz’ studies revolutionized the current understanding of degenerative conditions of the central nervous system. Her theory not only broke long-held dogmas, but also shattered a conceptual wall between the brain and the immune system, which plays a fundamental role throughout life in supporting brain plasticity – with far-reaching clinical implications for behavior, cognition, stress, neurodegenerative and neurodevelopmental diseases.
Professor Schwartz has received numerous prestigious awards for her research, including the Friedenwald Award from ARVO (Association for Research in Vision and Ophthalmology), the American Spinal Cord Injury Association’s Distinguished Heiner Sell Memorial Lectureship and the NARSAD (National Alliance for Research in Schizophrenia and Affective Disorders) Distinguished Investigator Award. Additionally, Schwartz was selected as one of the Career Women of the Year 2000 in Israel, and in 2006 as one of the top ten “Women to Watch”. Schwartz’ developments of her theory of “protective autoimmunity” has inspired the search for new therapeutic strategies, harnessing or modulating immune cells to fight ageing, and acute and chronic neurodegenerative diseases.
Carola Vinuesa was born in Spain and obtained a medical degree at the University Autonoma of Madrid. She undertook specialist clinical training in the UK and in 2000 was awarded a PhD by the University of Birmingham. A year later she was the recipient of a Wellcome Trust International Travelling prize Fellowship to do postdoctoral work at The John Curtin School for Medical Research in The Australian National University.
Since 2006 she has been a group leader. She has been the recipient of several prestigious awards including the Science Minister’s Prize for Life Scientist of the year (2008), the Gottschalk Medal of the Australian Academy of Sciences (2009). In 2015, she was elected as a Fellow of the Australian Academy of Science. She is currently Professor of Immunology at the Australian National University and Director of the Centre for Personalised Immunology (CPI), an NHMRC Centre for Research Excellence
Kenneth Walsh is the director of the Hematovascular Biology Center and a member of the Berne Cardiovascular Research Center at the University of Virginia. The Walsh Lab broadly examines the molecular events that drive cardiovascular cell growth, differentiation and cell death. At the forefront of this science, his newest studies have investigated how clonal hematopoiesis functions as a new causal risk factor for cardiovascular and metabolic diseases. He obtained his PhD in Biochemistry from the University of California, Berkeley. He is author of over 350 scientific articles.